Is the Serpin Folding Mechanism Conserved? The Folding Pathways of Human Alpha-1 Antitrypsin and Neuroserpin
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چکیده
منابع مشابه
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15 صفحه اولInteractions causing the kinetic trap in serpin protein folding.
Conformational transition is fundamental to the mechanism of functional regulation in proteins, and serpins (serine protease inhibitors) can provide insight into this process. Serpins are metastable in their native forms, and they ordinarily undergo conformational transition to a stable state only when they form a tight complex with target proteases. The metastable native form is thus considere...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.3016